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Issue 27, 2009
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Magnetic mesoporous silica microspheres with thermo-sensitive polymer shell for controlled drug release

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Abstract

A controlled drug release system was designed based on the combination of three advantages into one entity, which was composed of Fe3O4 magnetic nanoparticle as the core, mesoporous silica as the sandwiched layer, and thermo-sensitive P(NIPAM-co-NHMA) copolymer as the outer shell. The hydrophilic comonomer content affected the volume phase-transition temperature (VPTT) of this composite microsphere and the behavior of the temperature-triggered drug release. Zn(II) phthalocyanine tetrasulfonic acid (ZnPcS4), a well-known photodynamic therapy (PDT) drug, was used as a model drug to assess the release system. The results demonstrated that the drug release behavior was dependent on the temperature and had a close correlation with the VPTT. Above the VPTT, the drug release rate was much faster than that below the VPTT, which showed a great potential application in tumor therapy.

Graphical abstract: Magnetic mesoporous silica microspheres with thermo-sensitive polymer shell for controlled drug release

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Article information


Submitted
12 Feb 2009
Accepted
14 Apr 2009
First published
27 May 2009

J. Mater. Chem., 2009,19, 4764-4770
Article type
Paper

Magnetic mesoporous silica microspheres with thermo-sensitive polymer shell for controlled drug release

C. Liu, J. Guo, W. Yang, J. Hu, C. Wang and S. Fu, J. Mater. Chem., 2009, 19, 4764
DOI: 10.1039/B902985K

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