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Issue 35, 2009
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Nanostructured T1 MRI contrast agents

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Abstract

Recent advances on new T1 MRI contrast agents using nanostructured materials will be presented. Paramagnetic Gd3+ ions have been immobilized in nanostructured matrices such as liposomes, perfluorocarbons, silica-based nanoparticles, emulsions, and carbon nanotube to generate nanostructured ionic T1 MRI contrast agents with high relaxivity. Inorganic nanoparticles of gadolinium compounds and manganese oxides have been recently developed as new types of T1 MRI contrast agents using the large surface concentration of metal ions with high magnetic moments. Functionalization of these nanostructured T1 contrast agents enabled targeted imaging, multimodal imaging, and simultaneous imaging and drug delivery.

Graphical abstract: Nanostructured T1 MRI contrast agents

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Article information


Submitted
09 Feb 2009
Accepted
01 May 2009
First published
15 Jun 2009

J. Mater. Chem., 2009,19, 6267-6273
Article type
Feature Article

Nanostructured T1 MRI contrast agents

H. B. Na and T. Hyeon, J. Mater. Chem., 2009, 19, 6267
DOI: 10.1039/B902685A

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