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Issue 33, 2009
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Reverse thermogelling biodegradable polymer aqueous solutions

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Abstract

A reverse thermogelling polymer aqueous solution is a free-flowing sol at a low temperature and becomes a semisolid gel as the temperature increases. It is expected to be a very promising biomaterial as a minimally invasive injectable system for drug delivery and tissue engineering applications. The principles of materials design are (1) balancing the hydrophobicity and hydrophilicty of a polymer, (2) controlling the topology of a polymer, (3) matching the degradation kinetics of a polymer with a specific biomedical application, and (4) controlling the biocompatibility of the material with a drug as well as a host. This article covers recent progress of reverse theromogelling biodegradable polymers based on aliphatic polyesters, polyphosphazenes, poloxamer derivatives, polysaccharides, polypeptides, poly(propylene phosphate)s, polyorthoesters, polycarbonates, polycyanoacrylates, and poly(N-(2-hydroxyethyl) methacrylamide-lactate)s. The material characteristics, driving forces or mechanism for sol-gel transition, and their biomedical applications are summarized. In addition, the authors' perspectives on future reverse theromogelling materials design are suggested.

Graphical abstract: Reverse thermogelling biodegradable polymer aqueous solutions

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Publication details

The article was received on 04 Feb 2009, accepted on 01 May 2009 and first published on 10 Jun 2009


Article type: Feature Article
DOI: 10.1039/B902208B
Citation: J. Mater. Chem., 2009,19, 5891-5905

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    Reverse thermogelling biodegradable polymer aqueous solutions

    M. K. Joo, M. H. Park, B. G. Choi and B. Jeong, J. Mater. Chem., 2009, 19, 5891
    DOI: 10.1039/B902208B

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