Issue 22, 2008
From the journal:

Journal of Materials Chemistry

Stabilization of the amorphous state of pharmaceuticals in nanopores†

G. T. Rengarajan,a   D. Enke,b   M. Steinhartc  and  M. Beiner*a  

* Corresponding authors

a Institut für Physik, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
Fax: +49-345-5527351
Tel: +49-345-5525350

b Institut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany

c Max-Planck Institut für Mikrostrukturphysik, Weinberg 2, Halle (Saale), Germany

Abstract

Confinement in nanoporous host systems with strongly interacting pore walls is shown to be a powerful approach to increase the lifetime of amorphous drugs based on changes in thermodynamics and crystallization kinetics in nano-sized systems.

Graphical abstract: Stabilization of the amorphous state of pharmaceuticals in nanopores

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Article information

DOI
https://doi.org/10.1039/B804266G
Article type
Communication
Submitted
12 Mar 2008
Accepted
16 Apr 2008
First published
30 Apr 2008

J. Mater. Chem., 2008,18, 2537-2539

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Stabilization of the amorphous state of pharmaceuticals in nanopores

G. T. Rengarajan, D. Enke, M. Steinhart and M. Beiner, J. Mater. Chem., 2008, 18, 2537 DOI: 10.1039/B804266G

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