Issue 21, 2008

Fabrication of micropatterned ZnO/SiO2 core/shell nanorod arrays on a nanocrystalline diamond film and their application to DNA hybridization detection

Abstract

Micropatterned ZnO/SiO2 core/shell nanorod arrays are successfully fabricated on nanocrystalline diamond (NCD) film surfaces, and their performance as a fluorescence signal enhancing platform for DNA hybridization detection is also investigated. The fabrication process, from oriented ZnO nanorod deposition, amine silanation, and attachment of a biofunctional cross-linking molecule to the covalent immobilization of probe oligonucleotides, is defined. X-Ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are used to characterize ZnO/SiO2 core/shell nanorods. The sequence complementary and stability of the DNA-modified surface are demonstrated in hybridization experiments. The use of ZnO/SiO2 nanorod arrays not only greatly enhances the fluorescence signal collected but also decreases the nonspecific adsorption effect of ZnO nanomaterials after carrying out the hybridization reaction.

Graphical abstract: Fabrication of micropatterned ZnO/SiO2 core/shell nanorod arrays on a nanocrystalline diamond film and their application to DNA hybridization detection

Article information

Article type
Paper
Submitted
04 Jan 2008
Accepted
12 Mar 2008
First published
31 Mar 2008

J. Mater. Chem., 2008,18, 2459-2465

Fabrication of micropatterned ZnO/SiO2 core/shell nanorod arrays on a nanocrystalline diamond film and their application to DNA hybridization detection

J. Zhao, L. Wu and J. Zhi, J. Mater. Chem., 2008, 18, 2459 DOI: 10.1039/B800029H

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