Jump to main content
Jump to site search

Issue 16, 2008
Previous Article Next Article

A simple model framework for the prediction of controlled release from bulk eroding polymer matrices

Author affiliations

Abstract

A broadly applicable model for predicting controlled release could eliminate the need for exploratory, in vitro experiments during the design of new biodegradable matrix-based therapeutics. We have developed a simple mathematical model that can predict the release of many different types of agents from bulk eroding polymer matrices without regression. New methods for deterministically calculating the magnitude of the initial burst and the duration of the lag phase (time before Fickian release) were developed to enable the model's broad applicability. To complete the model's development, such that predictions can be made from easily measured or commonly known parameters, two correlations were developed by fitting the fundamental equations to published controlled release data. To test the model, predictions were made for several different biodegradable matrix systems. In addition, varying the readily attainable parameters over rational bounds shows that the model predicts a wide range of therapeutically relevant release behaviors.

Graphical abstract: A simple model framework for the prediction of controlled release from bulk eroding polymer matrices

Back to tab navigation

Publication details

The article was received on 28 Nov 2007, accepted on 07 Feb 2008 and first published on 04 Mar 2008


Article type: Paper
DOI: 10.1039/B718277E
Citation: J. Mater. Chem., 2008,18, 1873-1880

  •   Request permissions

    A simple model framework for the prediction of controlled release from bulk eroding polymer matrices

    S. N. Rothstein, W. J. Federspiel and S. R. Little, J. Mater. Chem., 2008, 18, 1873
    DOI: 10.1039/B718277E

Search articles by author

Spotlight

Advertisements