Issue 17, 2004
From the journal:

Journal of Materials Chemistry

Biotinylated CdSe/ZnSe nanocrystals for specific fluorescent labeling

Nicolas Charvet,a   Peter Reiss,*a   André Roget,a   Alain Dupuis,b   Didier Grünwald,b   Sophie Carayon,a   Frédéric Chandezona  and  Thierry Livachea  

* Corresponding authors

a CEA Grenoble, Département de Recherche Fondamentale sur la Matière Condensée, 17 rue des Martyrs, Grenoble, France
E-mail: preiss@cea.fr
Fax: +33 438 78 51 13
Tel: +33 438 78 97 19

b CEA Grenoble, Département Réponse et Dynamique Cellulaires, 17 rue des Martyrs, Grenoble, France

Abstract

A set of two new surface ligands is presented for the preparation of water-soluble, biotinylated CdSe/ZnSe core/shell nanocrystals, suitable for fluorescent biological labeling. It consists of a thiolated diethyleneglycol derivative and an alkylthiol substituted biotin molecule, which replace the initial capping ligands at the nanocrystal surface. Successful ligand exchange and long-term photostability of the modified nanocrystals as well as their highly specific binding to neuronal cells are demonstrated in different labeling experiments.

Graphical abstract: Biotinylated CdSe/ZnSe nanocrystals for specific fluorescent labeling

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Article information

DOI
https://doi.org/10.1039/B403714F
Article type
Paper
Submitted
10 Mar 2004
Accepted
27 May 2004
First published
18 Jun 2004

J. Mater. Chem., 2004,14, 2638-2642

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Biotinylated CdSe/ZnSe nanocrystals for specific fluorescent labeling

N. Charvet, P. Reiss, A. Roget, A. Dupuis, D. Grünwald, S. Carayon, F. Chandezon and T. Livache, J. Mater. Chem., 2004, 14, 2638 DOI: 10.1039/B403714F

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