Issue 9, 2008
From the journal:

Journal of Analytical Atomic Spectrometry

Imaging of essential and toxic elements in biological tissues by LA-ICP-MS†

J. Sabine Becker,*a   Miroslav Zoriy,a   Bei Wu,ad   Andreas Matuschb  and  J. Susanne Becker ‡c  

* Corresponding authors

a Central Division of Analytical Chemistry, Research Center Jülich, Jülich, Germany
E-mail: s.becker@fz-juelich.de

b Experimental Neurology, Department of Neurology, Philipps-University, Marburg, Germany

c Group of Bio-Inorganic Analytical Chemistry, CNRS UMR 5034, Hélioparc 2, Pau, France

d Institute of Environmental Science and Technology, Zhejiang University, Hangzhou, People's Republic of China

Abstract

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using double-focusing sector field (LA-ICP-SFMS) or quadrupole-based mass spectrometers (LA-ICP-QMS) was employed as powerful imaging (mapping) techniques to produce images of detailed regionally specific element distributions in thin tissue sections of different sizes such as control rat brain tissues or tumor regions to study tumor growing. LA-ICP-QMS was employed to investigate the uptake and the transport of nutrient elements in plant tissues or imaging of metals in proteins separated by native 2D BN-PAGE.

Graphical abstract: Imaging of essential and toxic elements in biological tissues by LA-ICP-MS

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Article information

DOI
https://doi.org/10.1039/B805228J
Article type
Technical Note
Submitted
27 Mar 2008
Accepted
21 Jul 2008
First published
05 Aug 2008

J. Anal. At. Spectrom., 2008,23, 1275-1280

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Imaging of essential and toxic elements in biological tissues by LA-ICP-MS

J. S. Becker, M. Zoriy, B. Wu, A. Matusch and J. S. Becker , J. Anal. At. Spectrom., 2008, 23, 1275 DOI: 10.1039/B805228J

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