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Issue 12, 2006
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Overcoming interferences in inductively coupled plasma mass spectrometryvia gas-flow modulation

Part 2. Correlation methods

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Abstract

The second of two methods for reducing oxide interferences in inductively coupled plasma mass spectrometry is outlined. In both methods, manipulation of the central-channel gas flow generates unique behavior from analytes and interfering oxides that can subsequently be used to isolate signal contributions from both species superimposed at a given mass. Here, mathematical correlation between an interferent-compromised analyte response and an internal standard allows errors from troublesome interferences to be effectively eliminated. This correction method is capable of addressing multiple analyteoxide interferences without sacrificing analyte sensitivity. A time-of-flight mass analyzer was used in this work to provide multi-elemental capabilities; however, the method is amenable to implementation on other simultaneous or scan-based mass analyzers.

Graphical abstract: Overcoming interferences in inductively coupled plasma mass spectrometry via gas-flow modulation Part 2. Correlation methods

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Article information


Submitted
23 Jun 2006
Accepted
16 Aug 2006
First published
13 Sep 2006

J. Anal. At. Spectrom., 2006,21, 1377-1386
Article type
Paper

Overcoming interferences in inductively coupled plasma mass spectrometry via gas-flow modulation

W. C. Wetzel, D. E. Shelby and G. M. Hieftje, J. Anal. At. Spectrom., 2006, 21, 1377
DOI: 10.1039/B613303G

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