Issue 9, 2002

Abstract

A new method has been developed for the simultaneous determination of AsV, monomethylarsenic (MMA), dimethylarsenic (DMA), AsIII, and arsenobetaine (AsB) in aqueous samples. The method utilizes a multi-mode ion exchange column coupled with a hexapole collision cell inductively coupled plasma mass spectrometer (ICP-MS). A mixture of 10 mM NH4NO3 and 0.05% HNO3 was used as the mobile phase, pumped by a high-performance liquid chromatography (HPLC) pump running in an isocratic mode at a flow rate of 0.4 mL min−1. Under these conditions, the five As species were separated within 14 min. The column outlet was connected directly to the ICP-MS via a low flow Meinhard concentric nebulizer. A river water certified reference material (SLRS-4), spiked with five As species at 20 µg L−1 (As cation) each, was used to validate the chromatographic separation and quantification in a real sample matrix. Based on replicate analyses of SLRS-4, the precision varied from 2% for AsV to 10% for MMA. The detection limits (3s) ranged from 0.02 µg L−1 for AsB to 0.4 µg L−1 for MMA. The new method was applied to water samples collected during As toxicity test experiments. The results indicated that transformation of inorganic As species (AsV and AsIII) occurred during the toxicity test experiments, but no methylation of inorganic As species was detected.

Article information

Article type
Technical Note
Submitted
01 Mar 2002
Accepted
25 Apr 2002
First published
17 May 2002

J. Anal. At. Spectrom., 2002,17, 1037-1041

Determination of five arsenic species in aqueous samples by HPLC coupled with a hexapole collision cell ICP-MS

Q. Xie, R. Kerrich, E. Irving, K. Liber and F. Abou-Shakra, J. Anal. At. Spectrom., 2002, 17, 1037 DOI: 10.1039/B202172B

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