4-Amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ols, 4-amino-2,3,4,5-tetrahydro-1-benzothiepin-5-ols, and related compounds

Abstract

A number of 4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ols and related compounds in the 1-benzothiepin series have been prepared, and methods of separation of the cis- and trans-isomers have been studied. Pharmacological studies have revealed that some of the compounds show activity on the central nervous system in mice. The synthesis of a number of multicyclic molecules containing the 2,3,4,5-tetrahydro-1-benzothiepin system is described.