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Issue 14, 1969
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Synthesis of thieno- and furo-pyrimidinethiones

Abstract

Substituted thiophens carrying adjacent amino- and cyano-groups have been converted into the corresponding pyrimidinethione derivatives in 30–70% yield by condensation with thioamides. Acylation of the thiophen followed by cyclisation in acidic solution gave the corresponding pyrimidones. The same reactions were used successfully with analogous furan compounds.

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Article information


J. Chem. Soc. C, 1969, 1937-1939
Article type
Paper

Synthesis of thieno- and furo-pyrimidinethiones

M. S. Manhas, V. V. Rao, P. A. Seetharaman, D. Succardi and J. Pazdera, J. Chem. Soc. C, 1969, 1937
DOI: 10.1039/J39690001937

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