SCHEDULED MAINTENANCE
Oxygenation of 6-methylpretetramid in aqueous alkaline medium occurs selectively with the formation of 1,4,6,11-tetrahydro-3,6,10,12-tetrahydroxy-6-methyl-1,4,11-trioxonaphthacene-2-carboxamide. This is readily reduced to 4-hydroxy-6-methylpretetramid which, like 6-methylpretetramid, is an intermediate in the biosynthesis of tetracycline.
C. H. Hassall and T. E. Winters, J. Chem. Soc. C, 1968, 1558 DOI: 10.1039/J39680001558
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