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Issue 4, 2016
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Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing

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Abstract

Investigations into cells and their contents have provided evolving insight into the emergence of complex biological behaviors. Capitalizing on this knowledge, synthetic biology seeks to manipulate the cellular machinery towards novel purposes, extending discoveries from basic science to new applications. While these developments have demonstrated the potential of building with biological parts, the complexity of cells can pose numerous challenges. In this review, we will highlight the broad and vital role that the synthetic biology approach has played in applying fundamental biological discoveries in receptors, genetic circuits, and genome-editing systems towards translation in the fields of immunotherapy, biosensors, disease models and gene therapy. These examples are evidence of the strength of synthetic approaches, while also illustrating considerations that must be addressed when developing systems around living cells.

Graphical abstract: Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing

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Article information


Submitted
24 Dec 2015
Accepted
31 Mar 2016
First published
04 Apr 2016

Integr. Biol., 2016,8, 504-517
Article type
Review Article
Author version available

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