Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 10, 2015
Previous Article Next Article

Modelling wound closure in an epithelial cell sheet using the cellular Potts model

Author affiliations


We use a two-dimensional cellular Potts model to represent the behavior of an epithelial cell layer and describe its dynamics in response to a microscopic wound. Using an energy function to describe properties of the cells, we found that the interaction between contractile tension along cell–cell junctions and cell–cell adhesion plays an important role not only in determining the dynamics and morphology of cells in the monolayer, but also in influencing whether or not a wound in the monolayer will close. Our results suggest that, depending on the balance between cell–cell adhesion and junctional tension, mechanics of the monolayer can either correspond to a hard or a soft regime that determines cell morphology and polygonal organization in the monolayer. Moreover, the presence of a wound in a hard regime, where junctional tension is significant, can lead to two results: (1) wound closure or (2) an initial increase and expansion of the wound area towards an equilibrium value. Theoretical approximations and simulations allowed us to determine the thresholds in the values of cell–cell adhesion and initial wound size that allow the system to lead to wound closure. Overall, our results suggest that around the site of injury, changes in the balance between contraction and adhesion determine whether or not non-monotonous wound closure occurs.

Graphical abstract: Modelling wound closure in an epithelial cell sheet using the cellular Potts model

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Feb 2015, accepted on 10 Jun 2015 and first published on 10 Jun 2015

Article type: Paper
DOI: 10.1039/C5IB00053J
Author version
Download author version (PDF)
Citation: Integr. Biol., 2015,7, 1253-1264

Search articles by author