Jump to main content
Jump to site search

Issue 2, 2015
Previous Article Next Article

Magnetic engineering of stable rod-shaped stem cell aggregates: circumventing the pitfall of self-bending

Author affiliations

Abstract

A current challenge for tissue engineering while restoring the function of diseased or damaged tissue is to customize the tissue according to the target area. Scaffold-free approaches usually yield spheroid shapes with the risk of necrosis at the center due to poor nutrient and oxygen diffusion. Here, we used magnetic forces developed at the cellular scale by miniaturized magnets to create rod-shaped aggregates of stem cells that subsequently matured into a tissue-like structure. However, during the maturation process, the tissue-rods spontaneously bent and coiled into sphere-like structures, triggered by the increasing cell–cell adhesion within the initially non-homogeneous tissue. Optimisation of the intra-tissular magnetic forces successfully hindered the transition, in order to produce stable rod-shaped stem cells aggregates.

Graphical abstract: Magnetic engineering of stable rod-shaped stem cell aggregates: circumventing the pitfall of self-bending

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Sep 2014, accepted on 24 Dec 2014 and first published on 02 Jan 2015


Article type: Paper
DOI: 10.1039/C4IB00219A
Author version
available:
Download author version (PDF)
Integr. Biol., 2015,7, 170-177

Search articles by author

Spotlight

Advertisements