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Issue 1, 2014
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Advances in magnetic tweezers for single molecule and cell biophysics

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Abstract

Magnetic tweezers (MTW) enable highly accurate forces to be transduced to molecules to study mechanotransduction at the molecular or cellular level. We review recent MTW studies in single molecule and cell biophysics that demonstrate the flexibility of this technique. We also discuss technical advances in the method on several fronts, i.e., from novel approaches for the measurement of torque to multiplexed biophysical assays. Finally, we describe multi-component nanorods with enhanced optical and magnetic properties and discuss their potential as future MTW probes.

Graphical abstract: Advances in magnetic tweezers for single molecule and cell biophysics

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Article information


Submitted
09 Sep 2013
Accepted
12 Nov 2013
First published
14 Nov 2013

Integr. Biol., 2014,6, 27-34
Article type
Frontier
Author version available

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