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Issue 4, 2013
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CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

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Abstract

We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.

Graphical abstract: CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells

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Publication details

The article was received on 27 Aug 2012, accepted on 15 Dec 2012 and first published on 13 Feb 2013


Article type: Paper
DOI: 10.1039/C3IB20203H
Integr. Biol., 2013,5, 669-672

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