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Issue 8, 2011
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De novo motif for kinase mediated signaling across the cell membrane

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The binding of a ligand to a cell-surface receptor represents a first step in transmitting extracellular information to the cell in order to activate downstream intracellular signaling events. This report describes the de novo engineering of cells with a transmembrane signal transduction motif that is developed from first principles. The signaling event is initiated with a polyvalent ligand that clusters an engineered receptor in the membrane. The receptor presents a cytosolic kinase substrate that undergoes autocatalytic phosphorylation when organized in a cluster, but not in the unclustered arrangement. The example described here may represent a motif that can be used in synthetic biology for the engineering of cells with novel circuits.

Graphical abstract: De novo motif for kinase mediated signaling across the cell membrane

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Supplementary files

Publication details

The article was received on 27 Jan 2011, accepted on 14 Jun 2011 and first published on 21 Jul 2011

Article type: Paper
DOI: 10.1039/C1IB00009H
Citation: Integr. Biol., 2011,3, 816-822
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