Environmentally sustainable production and application of acyl phosphates

Abstract

A versatile and environmentally friendly synthetic method for the formation of acyl phosphates is reported. By employing electrochemical oxidative dehydrogenative coupling, this transformation features a broad range of substrates, as well as metal-free, oxidant-free and mild conditions. One-pot synthesis of amides from acyl phosphates with amines was accomplished with high efficiency and regioselectivity, without using any additional catalysts and additives, within 2 hours under room temperature. The mechanism is proposed according to the control experiments.