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Issue 15, 2020

Electrochemical and direct C–H methylthiolation of electron-rich aromatics

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Abstract

The electrochemical-induced C–H methylthiolation of electron-rich aromatics has been accomplished via a three component cross-coupling strategy. Potassium thiocyanate (KSCN) as both the supporting electrolyte and sulfur source and methanol as the methylation reagent are used. This protocol is versatile for various (hetero)aromatic compounds such as aniline, anisole and indole. The reaction proceeds under mild conditions without any metal catalyst, exogenous oxidant and highly toxic sulfur reagent. Importantly, such an electrochemical-induced methylthiolated reaction could be easily scaled up with good efficiency.

Graphical abstract: Electrochemical and direct C–H methylthiolation of electron-rich aromatics

Supplementary files

Article information


Submitted
17 Feb 2020
Accepted
15 May 2020
First published
18 May 2020

Green Chem., 2020,22, 4906-4911
Article type
Paper

Electrochemical and direct C–H methylthiolation of electron-rich aromatics

Y. Wu, H. Ding, M. Zhao, Z. Ni and J. Cao, Green Chem., 2020, 22, 4906 DOI: 10.1039/D0GC00591F

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