Issue 15, 2020

Metal-free fluoroalkylfluoroalkylselenolation of unactivated alkenes: incorporation of two photoinduced processes

Abstract

The visible-light induced regioselective fluoroalkylfluoroalkylselenolation of unactivated alkenes was realized under metal and oxidant free conditions. The reaction was enabled by incorporation of two distinct photoinduced processes for the generation of two radical coupling partners. –CF3, –Rf, –CF2CO2Et, –CCl3, –SeCF3, and –SeRf were all successfully introduced to alkenes in good to excellent yields. The mild conditions showed a general substrate tolerance, and offered an efficient strategy for the late-stage functionalization of complex natural products and drug molecules.

Graphical abstract: Metal-free fluoroalkylfluoroalkylselenolation of unactivated alkenes: incorporation of two photoinduced processes

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2019
Accepted
06 Jul 2020
First published
14 Jul 2020

Green Chem., 2020,22, 4878-4883

Metal-free fluoroalkylfluoroalkylselenolation of unactivated alkenes: incorporation of two photoinduced processes

Y. Lei, J. Yang, Y. Wang, H. Wang, Y. Zhan, X. Jiang and Z. Xu, Green Chem., 2020, 22, 4878 DOI: 10.1039/C9GC03936H

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