A g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C–H oxygenations

Abstract

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C–H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C₃N₄) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C₃N₄ catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this “green” methodology was further demonstrated by applying in bioactive and drug valued target syntheses.