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Issue 3, 2019
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Metal-free synthesis of triarylated (Z)-nitrones via H2O-mediated 1,3-dipolar transfer under aerobic conditions

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Abstract

A new and environmentally benign protocol aimed at the generation of triarylated (Z)-nitrones in generally good yields has been developed via metal- and catalyst-free H2O-mediated 1,3-dipolar transfer reaction of para-quinone methides (p-QMs) with diarylated nitrones under aerobic conditions. The purification of these products only needs to be recrystallized by a mixed solvent comprising small amounts of petroleum ether and ethyl acetate, thereby avoiding the requirement of traditional chromatography. This new 1,3-dipolar strategy features broader substrate scope, green process, and mild conditions.

Graphical abstract: Metal-free synthesis of triarylated (Z)-nitrones via H2O-mediated 1,3-dipolar transfer under aerobic conditions

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Publication details

The article was received on 17 Nov 2018, accepted on 13 Jan 2019 and first published on 15 Jan 2019


Article type: Paper
DOI: 10.1039/C8GC03593H
Green Chem., 2019,21, 675-683

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    Metal-free synthesis of triarylated (Z)-nitrones via H2O-mediated 1,3-dipolar transfer under aerobic conditions

    K. Chen, W. Hao, S. Tu and B. Jiang, Green Chem., 2019, 21, 675
    DOI: 10.1039/C8GC03593H

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