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Issue 2, 2019
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A bifunctional strategy for N-heterocyclic carbene-stabilized iridium complex-catalyzed N-alkylation of amines with alcohols in aqueous media

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Abstract

Through the strategy of combining bifunctional 2-hydroxypyridine and a thermally stable N-heterocyclic carbene ligand, an Ir-catalyzed N-monoalkylation reaction has been developed in aqueous media under base-free conditions. This reaction proceeds smoothly with high yields of various aromatic amines and sulfonamides with a wide range of primary alcohols. Experimental and computational studies revealed a metal–ligand cooperative mechanism and its thermal stability during the bifunctional catalysis in aqueous media.

Graphical abstract: A bifunctional strategy for N-heterocyclic carbene-stabilized iridium complex-catalyzed N-alkylation of amines with alcohols in aqueous media

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Publication details

The article was received on 24 Jul 2018, accepted on 10 Dec 2018 and first published on 10 Dec 2018


Article type: Communication
DOI: 10.1039/C8GC02298D
Citation: Green Chem., 2019,21, 219-224

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    A bifunctional strategy for N-heterocyclic carbene-stabilized iridium complex-catalyzed N-alkylation of amines with alcohols in aqueous media

    M. Huang, Y. Li, J. Liu, X. Lan, Y. Liu, C. Zhao and Z. Ke, Green Chem., 2019, 21, 219
    DOI: 10.1039/C8GC02298D

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