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Issue 19, 2018
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Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

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Abstract

Halogenated aromatic compounds are the cores of many pharmaceutical, agricultural and chemical products but they are commonly prepared using electrophilic halogenation reactions in non-green chlorinated solvents under harsh conditions. A separate problem happens in the aromatic halogenation of thioarenes because they readily undergo oxidative side-reactions. Herein we report an environmentally benign electrophilic bromination of aromatics using an indole-catalytic protocol, which is suitable for a wide range of substrates including thioarenes.

Graphical abstract: Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

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Publication details

The article was received on 02 Aug 2018, accepted on 15 Sep 2018 and first published on 18 Sep 2018


Article type: Communication
DOI: 10.1039/C8GC02415D
Citation: Green Chem., 2018,20, 4448-4452

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    Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

    Y. Shi, Z. Ke and Y. Yeung, Green Chem., 2018, 20, 4448
    DOI: 10.1039/C8GC02415D

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