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Issue 23, 2017
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An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

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Abstract

An efficient and practical method for the one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thiones by cyclization of 2-aminothiophenols, 2-aminophenols, and 1,2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, excellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

Graphical abstract: An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

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Article information


Submitted
31 Jul 2017
Accepted
12 Oct 2017
First published
13 Oct 2017

Green Chem., 2017,19, 5591-5598
Article type
Paper

An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

X. Liu, M. Liu, W. Xu, M. Zeng, H. Zhu, C. Chang and Z. Dong, Green Chem., 2017, 19, 5591
DOI: 10.1039/C7GC02311A

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