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Issue 17, 2017
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Catalyst-free multi-component cascade C–H-functionalization in water using molecular oxygen: an approach to 1,3-oxazines

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Abstract

Herein, catalyst-free 3-component reactions of naphthols, aldehydes, and tetrahydroisoquinolines to synthesize 1,3-oxazines is reported. The reaction is performed in H2O in the presence of O2 as the sole oxidant at 100 °C, which proceeds through the formation of 1-aminoalkyl-2-naphthols followed by selective α-C–H functionalization of tert-amine.

Graphical abstract: Catalyst-free multi-component cascade C–H-functionalization in water using molecular oxygen: an approach to 1,3-oxazines

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Article information


Submitted
19 May 2017
Accepted
29 Jul 2017
First published
14 Aug 2017

Green Chem., 2017,19, 4036-4042
Article type
Communication

Catalyst-free multi-component cascade C–H-functionalization in water using molecular oxygen: an approach to 1,3-oxazines

M. L. Deb, C. D. Pegu, P. J. Borpatra, P. J. Saikia and P. K. Baruah, Green Chem., 2017, 19, 4036
DOI: 10.1039/C7GC01494E

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