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Issue 11, 2017
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Mechanoenzymatic peptide and amide bond formation

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Abstract

Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of α,α- and α,β-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.

Graphical abstract: Mechanoenzymatic peptide and amide bond formation

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Submitted
27 Feb 2017
Accepted
28 Apr 2017
First published
02 May 2017

Green Chem., 2017,19, 2620-2625
Article type
Paper

Mechanoenzymatic peptide and amide bond formation

J. G. Hernández, K. J. Ardila-Fierro, D. Crawford, S. L. James and C. Bolm, Green Chem., 2017, 19, 2620
DOI: 10.1039/C7GC00615B

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