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Issue 1, 2017
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A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines

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Abstract

We have reported herein a catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles by which a series of five-ring-fused tetrahydroisoquinolines featuring an indoline scaffold were obtained as single diastereomers in moderate to high yields without any additives under mild conditions. Moreover, the current method provides a novel and convenient approach for the efficient incorporation of two biologically important scaffolds (tetrahydroisoquinoline and indoline).

Graphical abstract: A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines

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Publication details

The article was received on 08 Sep 2016, accepted on 18 Oct 2016 and first published on 18 Oct 2016


Article type: Communication
DOI: 10.1039/C6GC02517J
Green Chem., 2017,19, 82-87

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    A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles: an easy access to five-ring-fused tetrahydroisoquinolines

    X. Liu, D. Yang, K. Wang, J. Zhang and R. Wang, Green Chem., 2017, 19, 82
    DOI: 10.1039/C6GC02517J

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