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Issue 14, 2016
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Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study

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Abstract

Two arrays of behenoyl (22 : 0) based amphiphilic lipids with sugar alcohols as a flexible linker were synthesized through acylation of sugar alcohol mono-behenates with diacetyl tartaric anhydride or acetoxy succinic anhydride and some of the resulting products are capable of yielding stable and uniform solid lipid nanoparticles (SLNs) (mean diameter ∼100 nm, PDI < 0.2) without any additive surfactant, displaying excellent dual functions (as both a solid lipid excipient and emulsifier).

Graphical abstract: Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study

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Submitted
27 Mar 2016
Accepted
12 Jun 2016
First published
13 Jun 2016

Green Chem., 2016,18, 3962-3971
Article type
Communication

Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study

W. Wei, X. Lu, Z. Wang, M. Dong, F. Feng and Z. Guo, Green Chem., 2016, 18, 3962
DOI: 10.1039/C6GC00866F

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