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Issue 18, 2016
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Decarboxylative/decarbonylative C3-acylation of indoles via photocatalysis: a simple and efficient route to 3-acylindoles

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Abstract

A simple and efficient strategy for the preparation of 3-acylindoles via visible-light promoted C3-acylation of free (NH)- and N-substituted indoles with α-oxocarboxylic acids was developed. The reaction tolerates a wide range of functional groups, and the corresponding 3-acylindoles were obtained in high yields under mild conditions.

Graphical abstract: Decarboxylative/decarbonylative C3-acylation of indoles via photocatalysis: a simple and efficient route to 3-acylindoles

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Article information


Submitted
24 Feb 2016
Accepted
24 May 2016
First published
24 May 2016

Green Chem., 2016,18, 4916-4923
Article type
Paper

Decarboxylative/decarbonylative C3-acylation of indoles via photocatalysis: a simple and efficient route to 3-acylindoles

Q. Shi, P. Li, X. Zhu and L. Wang, Green Chem., 2016, 18, 4916
DOI: 10.1039/C6GC00516K

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