Issue 9, 2016
From the journal:

Green Chemistry

A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines†

Xiaofeng Zhang,a   Sanjun Zhi,b   Wei Wang,c   Shuai Liu,a   Jerry P. Jasinskid  and  Wei Zhang*a  

* Corresponding authors

a Centre for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
E-mail: wei2.zhang@umb.edu

b Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Huaian, Jiangsu 223300, PR China

c School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, PR China

d Department of Chemistry, Keene State College, Keene, NH 03435, USA

Abstract

A pot-economical synthesis involving sequential [3 + 2] cycloadditions of an azomethine ylide and an azide–alkyne (click reaction) has been developed for diastereoselective synthesis of novel triazolobenzodiazepine-containing polycyclic compounds. A new example of catalyst-free click chemistry of non-strained alkynes is also disclosed.

Graphical abstract: A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines

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Article information

DOI
https://doi.org/10.1039/C6GC00497K
Article type
Communication
Submitted
22 Feb 2016
Accepted
08 Mar 2016
First published
09 Mar 2016

Green Chem., 2016,18, 2642-2646

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A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines

X. Zhang, S. Zhi, W. Wang, S. Liu, J. P. Jasinski and W. Zhang, Green Chem., 2016, 18, 2642 DOI: 10.1039/C6GC00497K

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