Jump to main content
Jump to site search

Issue 9, 2016
Previous Article Next Article

Transition metal-free, iodide-mediated domino carbonylation–benzylation of benzyl chlorides with arylboronic acids under ambient pressure of carbon monoxide

Author affiliations

Abstract

A conceptually distinct approach toward the synthesis of 1,2,3-triarylpropan-1-one by NaI-catalyzed domino carbonylation–benzylation of unactivated benzyl chlorides with arylboronic acids has been developed under ambient pressure of CO gas. The novel method represents a significant improvement over the traditional palladium-catalyzed carbonylation: the catalyst NaI is abundant, inexpensive, and bench stable, the reaction conditions are much milder, and the use of ligands and the costly need to remove metallic impurities from the end products are avoided. This apparently transition-metal-free process offers a new strategy for carbonylative cross-coupling reactions of C(sp3) halides.

Graphical abstract: Transition metal-free, iodide-mediated domino carbonylation–benzylation of benzyl chlorides with arylboronic acids under ambient pressure of carbon monoxide

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Jan 2016, accepted on 10 Feb 2016 and first published on 10 Feb 2016


Article type: Communication
DOI: 10.1039/C6GC00017G
Author version
available:
Download author version (PDF)
Green Chem., 2016,18, 2598-2603

  •   Request permissions

    Transition metal-free, iodide-mediated domino carbonylation–benzylation of benzyl chlorides with arylboronic acids under ambient pressure of carbon monoxide

    F. Jin, Y. Zhong, X. Zhang, H. Zhang, Q. Zhao and W. Han, Green Chem., 2016, 18, 2598
    DOI: 10.1039/C6GC00017G

Search articles by author

Spotlight

Advertisements