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Issue 7, 2016
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Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes

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Abstract

A one-pot three component reaction has been developed for the synthesis of substituted cyclopropanes employing 4-bromomethyl-2H-chromen-2-one/quinolin-2(1H)-ones, aromatic aldehydes and activated nitriles. The room temperature reaction in aqueous medium has been found to be diastereoselective and high yielding.

Graphical abstract: Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes

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The article was received on 10 Oct 2015, accepted on 26 Nov 2015 and first published on 27 Nov 2015


Article type: Paper
DOI: 10.1039/C5GC02443A
Green Chem., 2016,18, 2201-2205

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    Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes

    A. Anand, J. Yenagi, J. Tonannavar and M. V. Kulkarni, Green Chem., 2016, 18, 2201
    DOI: 10.1039/C5GC02443A

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