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Issue 5, 2016
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Organobase catalysis using 1-(2-pyrimidyl)piperazine in micellar medium: an approach for better performance and reusability of organobase

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Abstract

An organobase–surfactant micellar combined system was investigated for efficient and alkali/metal free base catalysis and to establish a simple method for separation and reuse of an organobase catalyst. Various aqueous organobase–surfactant micellar solutions were studied by using the Knoevenagel condensation of salicylaldehyde with active methylene compounds to 3-substituted coumarin as a model reaction. The 1-(2-pyrimidyl) piperazine (2-PP) was identified as a highly active organobase and its activity was further improved by using it in an aqueous solution of sodium dodecyl sulfate (SDS). The SDS micelles facilitate the reaction in water by solubilizing the 2-PP organobase and the reactants in their active forms. The reactant–SDS interactions in micelles play a significant role in promotion of the 2-PP catalyzed reaction. The SDS micellar medium not only promotes the 2-PP catalyzed reaction but also provides an easy and practicable protocol for the separation and reuse of the 2-PP organobase.

Graphical abstract: Organobase catalysis using 1-(2-pyrimidyl)piperazine in micellar medium: an approach for better performance and reusability of organobase

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Supplementary files

Article information


Submitted
21 Aug 2015
Accepted
02 Oct 2015
First published
02 Oct 2015

Green Chem., 2016,18, 1339-1354
Article type
Paper
Author version available

Organobase catalysis using 1-(2-pyrimidyl)piperazine in micellar medium: an approach for better performance and reusability of organobase

M. Vashishtha, M. Mishra and D. O. Shah, Green Chem., 2016, 18, 1339
DOI: 10.1039/C5GC01966D

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