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Issue 2, 2016
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Solvent-free synthesis of pillar[6]arenes

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Abstract

An efficient solvent-free procedure for the synthesis of pillar[6]arenes has been developed. The procedure involves the solid-state condensation of finely milled 1,4-dialkoxybenzene and paraformaldehyde by grinding in the presence of a catalytic amount of H2SO4. The use of organic solvents for the extraction of products has also been avoided. Operational simplicity, compatibility with various 1,4-dialkoxybenzenes, non-chromatographic purification technique, high yields and mild reaction conditions are the notable advantages of this procedure. A large scale reaction demonstrated the practical applicability of this methodology.

Graphical abstract: Solvent-free synthesis of pillar[6]arenes

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Article information


Submitted
03 Jul 2015
Accepted
21 Aug 2015
First published
24 Aug 2015

Green Chem., 2016,18, 423-426
Article type
Communication
Author version available

Solvent-free synthesis of pillar[6]arenes

S. Santra, D. S. Kopchuk, I. S. Kovalev, G. V. Zyryanov, A. Majee, V. N. Charushin and O. N. Chupakhin, Green Chem., 2016, 18, 423
DOI: 10.1039/C5GC01505G

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