Issue 6, 2015

Atom economical synthesis of oxindoles by metal-catalyzed intramolecular C–C bond formation under solvent-free and aerobic conditions

Abstract

Diversely substituted oxindoles were obtained from atom economical direct C–C bond formation reactions of various substituted anilides and pyridinylamides with metal salts and oxides. The catalysts include CuO, Cu2O, FeCl3, Fe2O3, TiO2, ZnO, and Ag2O and their nanoparticles. The reaction proceeds under solvent-free and aerobic conditions in excellent yields. The reaction mechanism was proved to be a single electron transfer pathway with oxygen as the re-oxidant of the metal catalysts.

Graphical abstract: Atom economical synthesis of oxindoles by metal-catalyzed intramolecular C–C bond formation under solvent-free and aerobic conditions

Supplementary files

Article information

Article type
Communication
Submitted
01 Apr 2015
Accepted
01 May 2015
First published
01 May 2015

Green Chem., 2015,17, 3306-3309

Author version available

Atom economical synthesis of oxindoles by metal-catalyzed intramolecular C–C bond formation under solvent-free and aerobic conditions

S. I. Son, W. K. Lee, J. Choi and H. Ha, Green Chem., 2015, 17, 3306 DOI: 10.1039/C5GC00703H

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