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Issue 2, 2015
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One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

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Abstract

We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up to two C–C bond forming steps allows for the rapid generation of molecular complexity under mild conditions.

Graphical abstract: One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

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Article information


Submitted
25 Nov 2014
Accepted
12 Dec 2014
First published
18 Dec 2014

This article is Open Access

Green Chem., 2015,17, 852-855
Article type
Communication
Author version available

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

B. R. Lichman, E. D. Lamming, T. Pesnot, J. M. Smith, H. C. Hailes and J. M. Ward, Green Chem., 2015, 17, 852
DOI: 10.1039/C4GC02325K

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