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Issue 12, 2014
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A ball-milling strategy for the synthesis of benzothiazole, benzimidazole and benzoxazole derivatives under solvent-free conditions

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Abstract

A convenient solvent-free method for the synthesis of benzothiazole, benzimidazole, and benzoxazole derivatives has been developed using recyclable ZnO-NPs via a ball-milling strategy. The method affords environmentally friendly reaction conditions that score high on the ecoscale with the low E-factor. The process is also highly efficient even on a multi-gram scale and provides easy product isolation.

Graphical abstract: A ball-milling strategy for the synthesis of benzothiazole, benzimidazole and benzoxazole derivatives under solvent-free conditions

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Article information


Submitted
18 Jun 2014
Accepted
04 Aug 2014
First published
22 Aug 2014

Green Chem., 2014,16, 4922-4930
Article type
Paper

A ball-milling strategy for the synthesis of benzothiazole, benzimidazole and benzoxazole derivatives under solvent-free conditions

H. Sharma, N. Singh and D. O. Jang, Green Chem., 2014, 16, 4922
DOI: 10.1039/C4GC01142B

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