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Issue 9, 2014
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Development of a tripartite solvent blend for sustainable chromatography

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Abstract

A three-component solvent system (isopropyl acetate, methanol, and heptane) was designed to empower routine chromatographic separation of a wide range of compounds, from polar to nonpolar molecules, without the need for undesired chlorinated solvent. This system was evaluated with a pharmaceutically-relevant set of compounds via practical silica gel chromatographic purification, making the solvent blend an attractive sustainable chromatography solution for drug discovery efforts.

Graphical abstract: Development of a tripartite solvent blend for sustainable chromatography

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Publication details

The article was received on 14 May 2014, accepted on 11 Jul 2014 and first published on 11 Jul 2014


Article type: Communication
DOI: 10.1039/C4GC00884G
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Green Chem., 2014,16, 4102-4105

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    Development of a tripartite solvent blend for sustainable chromatography

    F. M. Chardon, N. Blaquiere, G. M. Castanedo and S. G. Koenig, Green Chem., 2014, 16, 4102
    DOI: 10.1039/C4GC00884G

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