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Issue 2, 2013
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More efficient redox biocatalysis by utilising 1,4-butanediol as a ‘smart cosubstrate’

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Abstract

1,4-Butanediol is shown to be an efficient cosubstrate to promote NAD(P)H-dependent redox biocatalysis. The thermodynamically and kinetically inert lactone coproduct makes the regeneration reaction irreversible. Thereby not only the molar surplus of cosubstrate is dramatically reduced but also faster reaction rates are obtained.

Graphical abstract: More efficient redox biocatalysis by utilising 1,4-butanediol as a ‘smart cosubstrate’

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Article information


Submitted
12 Nov 2012
Accepted
19 Dec 2012
First published
20 Dec 2012

This article is Open Access

Green Chem., 2013,15, 330-335
Article type
Communication

More efficient redox biocatalysis by utilising 1,4-butanediol as a ‘smart cosubstrate’

S. Kara, D. Spickermann, J. H. Schrittwieser, C. Leggewie, W. J. H. van Berkel, I. W. C. E. Arends and F. Hollmann, Green Chem., 2013, 15, 330
DOI: 10.1039/C2GC36797A

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