Issue 11, 2012
From the journal:

Green Chemistry

One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds†

Wen-Bin Yi,*a   Xin Huang,b   Chun Caia  and  Wei Zhang*b  

* Corresponding authors

a School of Chemical Engineering, Nanjing University of Science and Technology, Xiao Ling Wei Street, Nanjing 210094, People's Republic of China
E-mail: yiwenbin@mail.njust.edu.cn
Fax: +86-25-84315030
Tel: +86-25-84315514

b Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA
E-mail: wei2.zhang@umb.edu
Fax: +1-617-287-6030
Tel: +1-617-286-6147

Abstract

Fluorination followed by the Michael addition or Robinson annulation of 1,3-dicarbonyl compounds is introduced for the synthesis of acyclic and cyclic α-fluoro-β-ketoesters and α-fluoro-1,3-diketones. The decarboxylation step can also be added to the reaction sequence. High efficiency is achieved by the microwave heating and atom economic one-pot synthesis.

Graphical abstract: One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds

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Article information

DOI
https://doi.org/10.1039/C2GC36166C
Article type
Paper
Submitted
26 Jul 2012
Accepted
08 Sep 2012
First published
12 Sep 2012

Green Chem., 2012,14, 3185-3189

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One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds

W. Yi, X. Huang, C. Cai and W. Zhang, Green Chem., 2012, 14, 3185 DOI: 10.1039/C2GC36166C

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