Issue 12, 2012

Lactic acid as an invaluable bio-based solvent for organic reactions

Abstract

Lactic acid was used, for the first time, as a bio-based green solvent to promote some organic reactions, such as three-component reactions of styrenes, formaldehyde and an active phenolic compound or N,N-dialkylacetoacetamides, three-component reactions of diethyl acetylenedicarboxylate, anilines and aromatic aldehydes, aniline-catalyzed condensations between salicylaldehydes and diethyl acetylenedicarboxylate, and the synthesis of substituted quinolines through Friedländer annulation between 2′-aminoacetophenone and 1,3-dicarbonyl compounds. In these reactions, lactic acid solvent exhibited many advantages including bio-based origin, superior synthetic efficiency, ease of isolating the product and good recyclability of the reaction medium. The concept of using lactic acid as a green solvent not only enriches the diversity and versatility of bio-based green solvents, but also offers us an effective means for designing environmentally benign synthetic systems.

Graphical abstract: Lactic acid as an invaluable bio-based solvent for organic reactions

Supplementary files

Article information

Article type
Paper
Submitted
13 Jul 2012
Accepted
19 Oct 2012
First published
22 Oct 2012

Green Chem., 2012,14, 3304-3317

Lactic acid as an invaluable bio-based solvent for organic reactions

J. Yang, J. Tan and Y. Gu, Green Chem., 2012, 14, 3304 DOI: 10.1039/C2GC36083G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements