Issue 10, 2011

Protective opening of epoxide using pivaloyl halides under catalyst-free conditions

Abstract

An efficient and environmentally benign protocol for protective opening of epoxide (POE) with pivaloyl halides in solvent-free conditions and in aqueous media under catalyst-free conditions has been developed. The green reaction conditions, simple work-up procedures, high yields and broad scope of the reaction illustrate the good synthetic utility of this method. The key advantages of the reaction are regioselectivity and reconvertability of products into their prior epoxides in the presence of mild reaction conditions.

Graphical abstract: Protective opening of epoxide using pivaloyl halides under catalyst-free conditions

Supplementary files

Article information

Article type
Communication
Submitted
04 May 2011
Accepted
25 Jul 2011
First published
22 Aug 2011

Green Chem., 2011,13, 2704-2707

Protective opening of epoxide using pivaloyl halides under catalyst-free conditions

C. B. Rao, D. C. Rao, M. Venkateswara and Y. Venkateswarlu, Green Chem., 2011, 13, 2704 DOI: 10.1039/C1GC15506G

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