Issue 5, 2011
From the journal:

Green Chemistry

Flow microreactor synthesis of disubstituted pyridines from dibromopyridinesviaBr/Li exchange without using cryogenic conditions†

Aiichiro Nagaki,a   Shigeyuki Yamada,a   Masatomo Doi,a   Yutaka Tomida,a   Naofumi Takabayashia  and  Jun-ichi Yoshida*a  

* Corresponding authors

a Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp
Fax: +81 75-383-2727
Tel: +81 75-383-2726

Abstract

A flow microreactor method for the synthesis of disubstituted pyridines by generation of pyridyllithiums followed by reactions with electrophiles has been developed. By using a short residence time and efficient temperature control, the cryogenic conditions required for conventional batch macro processes can be avoided. Sequential introduction of two different electrophiles into dibromopyridines has been achieved using an integrated flow microreactor system composed of four micromixers and four microtube reactors, to obtain disubstituted pyridine compounds.

Graphical abstract: Flow microreactor synthesis of disubstituted pyridines from dibromopyridinesviaBr/Li exchange without using cryogenic conditions

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Article information

DOI
https://doi.org/10.1039/C0GC00852D
Article type
Communication
Submitted
26 Nov 2010
Accepted
07 Mar 2011
First published
28 Mar 2011

Green Chem., 2011,13, 1110-1113

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Flow microreactor synthesis of disubstituted pyridines from dibromopyridinesviaBr/Li exchange without using cryogenic conditions

A. Nagaki, S. Yamada, M. Doi, Y. Tomida, N. Takabayashi and J. Yoshida, Green Chem., 2011, 13, 1110 DOI: 10.1039/C0GC00852D

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