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Issue 12, 2010
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Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidations

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Abstract

The present study describes the first-time usage of an isolated thermostable Baeyer–Villiger monooxygenase (phenylacetone monooxygenase, PAMO) in the presence of ionic liquids. The stability, activity and selectivity of PAMO as an oxidative enzyme in the presence of different ionic liquids were studied. This revealed that the addition of some specific ionic liquids, such Ammoeng™ 102 and [bmim]MeSO4, can significantly enhance the E-value in the oxidation of racemic benzylketones. Moreover, the use of ionic liquids increases the optimal substrate concentration for performing Baeyer–Villiger oxidation, thereby extending the biocatalytic repertoire of PAMO for synthetic applications.

Graphical abstract: Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidations

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Publication details

The article was received on 16 Sep 2010, accepted on 22 Oct 2010 and first published on 12 Nov 2010


Article type: Paper
DOI: 10.1039/C0GC00560F
Green Chem., 2010,12, 2255-2260

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    Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidations

    C. Rodríguez, G. de Gonzalo, M. W. Fraaije and V. Gotor, Green Chem., 2010, 12, 2255
    DOI: 10.1039/C0GC00560F

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