Issue 11, 2010
From the journal:

Green Chemistry

Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen†

Shengjiao Yan,‡a   Yulan Chen,‡a   Lin Liu,a   Nengqin Hea  and  Jun Lin*a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
E-mail: linjun@ynu.edu.cn
Fax: +86 871 5033215
Tel: +86 871 5033215

Abstract

An efficient one-pot, three-component synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen, starting from simple and readily available materials, is described. Cyclocondensation of heterocyclic ketene aminals (HKAs), triethoxymethane, and active methylene compounds by refluxing under solvent-free and catalyst-free conditions, provided bicyclic pyridines in excellent yields.

Graphical abstract: Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen

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Article information

DOI
https://doi.org/10.1039/C0GC00373E
Article type
Paper
Submitted
28 Jul 2010
Accepted
15 Sep 2010
First published
11 Oct 2010

Green Chem., 2010,12, 2043-2052

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Three-component solvent-free synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen

S. Yan, Y. Chen, L. Liu, N. He and J. Lin, Green Chem., 2010, 12, 2043 DOI: 10.1039/C0GC00373E

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