Issue 11, 2010
From the journal:

Green Chemistry

Mild water-promoted selective deacetalisatison of acyclic acetals†

D. Bradley G. Williams,*a   Adam Cullen,a   Alex Fourie,a   Hendrik Henning,a   Michelle Lawton,a   Wayne Mommsen,a   Portia Nangu,a   Jonathan Parkera  and  Alicia Renisona  

* Corresponding authors

a Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park, South Africa
E-mail: bwilliams@uj.ac.za

Abstract

Various aliphatic and aromatic dimethyl and diethyl acetals and ketals were found to hydrolyse in essentially quantitative yield when heated to 80 °C in neat water or aqueous medium without a catalyst or any other additive, while cyclic acetals were stable under these conditions. Selective deprotection is possible when both types of acetal are present.

Graphical abstract: Mild water-promoted selective deacetalisatison of acyclic acetals

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Article information

DOI
https://doi.org/10.1039/C0GC00280A
Article type
Communication
Submitted
01 Jul 2010
Accepted
15 Sep 2010
First published
30 Sep 2010

Green Chem., 2010,12, 1919-1921

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Mild water-promoted selective deacetalisatison of acyclic acetals

D. B. G. Williams, A. Cullen, A. Fourie, H. Henning, M. Lawton, W. Mommsen, P. Nangu, J. Parker and A. Renison, Green Chem., 2010, 12, 1919 DOI: 10.1039/C0GC00280A

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