Regio- and diastereoselective ring-opening of (S)-(−)-2-(trifluoromethyl)oxirane with chiral 2,5-disubstituted tetrahydroquinolines in hexafluoro-2-propanol
Abstract
Multi-hundred grams of
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* Corresponding authors
a
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P. O. Box 776, Spring House, Pennsylvania, USA
E-mail:
xli6@its.jnj.com
Fax: +1 (215) 540-4611
Tel: +1 (215) 628-7829
b Johnson & Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutical, API Development, Turnhoutseweg 30, Beerse, Belgium
Multi-hundred grams of
X. Li, R. K. Russell, H. Chen, Y. Zhang, S. Ballentine, J. Spink, S. Branum, F. Liu, Y. Chen, T. Rammeloo, W. Aelterman, K. L. Sorgi and W. V. Murray, Green Chem., 2010, 12, 1548 DOI: 10.1039/C004726K
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